CD4 抗体
Quick Overview for CD4 抗体 (ABIN1106337)
抗原
See all CD4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody reacts with CD4 antigen.
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交叉反应 (详细)
- Species reactivity (tested):Human
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纯化方法
- Protein A agarose
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免疫原
- PHA-activated human CD4+ T-cells
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
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储存液
- Without preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store (in aliquots) at -20 °C.
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- CD4
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别名
- CD4
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背景
- The T cell receptor for antigen (TCR) is a membrane-bound member of the immunoglobulin superfamily (IgSF) that recognizes a complex of antigen bound to self major histocompatibility complex (MHC) molecules expressed on the cell-surface of antigen-presenting cells (APC). Both cytotoxic and helper T cells typically respond to antigen which is associated with different types of MHC molecules, class I and II, respectively. CD4 is a 55-60 kDa cell-surface glycoprotein, which participates in the molecular complexes involved both in T cell development and its antigen recognizing activity, by binding to the nonpolymorphic region of class II MHC. This interaction results in increased intercellular adhesion and enhanced stimulation of T cells by signal transduction which is mediated by intracellular molecules. CD4 is also considered as a stage marker of T cell development in thymus, for it is expressed on the cell surface in a stage specific manner, during T cell development.Synonyms: T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4
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基因ID
- 920
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NCBI登录号
- NP_000607
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UniProt
- P01730
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途径
- TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events
抗原
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